Communicating About Phase I Trials: Objective Disclosures Are Only A First Step

Disclosure: only a first step.

Are First Impressions about Websites Only Related to Visual Appeal?

This paper investigates whether immediate impression about websites influences only perceptions of attractiveness. The evaluative constructs of perceived usability, credibility and novelty were investigated alongside visual appeal in an experimental setting in which users evaluated 20 website screenshots in two phases. The websites were rated by the participants after viewing time of 500 ms in ...

Phase I clinical trials

Phase I trials are conducted to find a dose to use in subsequent trials. They provide data on the rate of adverse events at different dose levels and provide data for studying the pharmacokinetics and pharmacology of the drug. Dose-finding studies that involve therapies with little or no toxicity often enroll healthy volunteers and usually have a control group. Trials in oncology and other life...

Children's opinions about organ donation: a first step to assent?

BACKGROUND Parents have to decide about organ donation after the death of their child. Although most parents probably would like to respect their child's intentions, parents often are not aware of their child's wishes. This requires insight into children's opinions about donation. METHODS An internet survey that investigated whether Dutch children in the age range of 12 through 15 years had h...

Terminological Default Reasoning about Spatial Information: A First Step

We extend the theory about terminological default reasoning by using a logical base language that can represent spatioterminological phenomena. Based on this description logic language called ALCRP(S2), which is briefly introduced, we discuss algorithms for computing so-called extensions (“possible worlds”) of a world description and a set of defaults. We conclude with an application of the the...